ABSTRACT
El consumo excesivo de bebidas alcohólicas constituye un serio problema sanitario y social. En los últimos años se han destacado sus propiedades anticancerosas, antioxidantes y protectoras contra la enfermedad cardíaca coronaria, lo que ha generado controversias entre beneficios y perjuicios de su consumo. Los efectos tóxicos sobre el sistema nervioso central lideran el cuadro de la intoxicación aguda, mientras que los efectos del consumo crónico afectan prácticamente todo el organismo, alterando numerosas funciones aún en etapas tempranas de la vida. Los profesionales de las ciencias de la salud tienen un rol clave en la prevención de los daños producidos por este hábito tan difundido.
Subject(s)
Humans , Alcoholism/complications , Alcoholic Beverages/toxicity , Oral Health , Alcoholic Beverages/adverse effects , Liver Cirrhosis, Alcoholic/prevention & control , Mouth Diseases/etiology , Ethanol/metabolism , World Health OrganizationABSTRACT
O artigo descreve a construção de um questionário para avaliação da qualidade do atendimento de um Time de Resposta Rápida, em Hospital Universitário de Londrina-PR, fundamentado no modelo conceitual de Donabedian (estrutura-processoresultado). A coleta de dados ocorreu no mês de março de 2012 e o processo de adequação do questionário foi desenvolvido com a aplicação da Técnica Delphi com a participação de 15 especialistas. Ao término do estudo obteve-se um questionário com 37 enunciados, sendo alcançado índice de concordância final na pesquisa com valores superiores a 80% para todos os conceitos. Espera-se que as contribuições do grupo de especialistas tornem o instrumento confiável e seja aplicado em outros serviços semelhantes. Aplicações futuras deste instrumento poderão trazer subsídios para melhor avaliação da qualidade dos serviços de equipes de Resposta Rápida.
The paper describes the construction of a questionnaire to assess the quality of care of a Rapid Response Team at the University Hospital of Londrina, based on the conceptual model of Donabedian (structure-process-outcome). Data collection occurred in March 2012 and the process of adjusting the questionnaire was developed with the application of the Delphi technique involving 15 experts. At the end of the study the questionnaire contained 37 statements, achieving final compliance level higher than 80% in all concepts. It is hoped that the contributions of the expert group produce a more reliable questionnaire to be applied in other similar services. Future applications of this instrument may provide information to better assess the quality of teams of Rapid Response services.
El artículo describe la construcción de un cuestionario para la evaluación de la calidad de la atención de un Equipo de Respuesta Rápida en un Hospital Universitario de Londrina, Paraná, basado en el modelo conceptual de Donabedian (estructura-procesoresultado). La recolección de datos ocurrió durante el mes de marzo de 2012 y el proceso de ajuste del cuestionario fue desarrollado por medio de la Técnica Delphi con la participación de 15 especialistas. Al término del estudio se obtuvo un cuestionario con 37 enunciados, alcanzándose un índice de concordancia final en la investigación con valores superiores al 80% para todos los conceptos. Se espera que las contribuciones del grupo de especialistas afiancen la confiabilidad del instrumento y que el cuestionario sea utilizado en otros servicios semejantes. Las aplicaciones futuras podrán traer subsidios para evaluar mejor la calidad de los servicios de los equipos de Respuesta Rápida.
Subject(s)
Humans , Animals , Male , Rats , Alcoholic Beverages/toxicity , Hepatocytes/drug effects , Metallothionein/biosynthesis , Cell Division/drug effects , Collagen/biosynthesis , Hepatocytes/metabolism , Hepatocytes/pathology , Liver Cirrhosis, Alcoholic/etiology , Liver Cirrhosis, Alcoholic/prevention & control , Rats, Sprague-DawleyABSTRACT
Excoecaria agallocha L. [Family: Euphorbiaceae] is a Bangladeshi medicinal plant found predominantly in the tidal forests and swamps of the Sundarbans and other coastal areas in Bangladesh. As part of our on-going phytochemical and bioactivity studies on medicinal plants from Bangladeshi flora, the in vitro antioxidant property on the bark of this plant was evaluated. The hydroalcohol extract of the dried and ground bark of E. agallocha was assessed for antioxidant activity using a series of well-established assays including the 2, 2-diphenyl-1-picrylhydrazyl [DPPH], the lipid peroxidation by thiobarbituric acid [TBA], the reducing power, the nitric oxide [NO.] and the hydrogen peroxide [H[2] O[2]] scavenging assays. In the DPPH, the NO and the H[2]O[2] scavenging assays, the extract of E. agallocha displayed significant antioxidant activities with the IC[50] values of 179.16, 120.24 and 134.29 microg/ml, respectively. The reducing power of the extract increased dose-dependently, and the extract reduced the most Fe[3+] ions to the extent less than butylated hydroxy toluene [BHT]. In the lipid peroxidation assay, the extract showed significant inhibition of peroxidation effect at all concentrations, with an IC[50] value of 189.27 microg/ml. Since reactive oxygen species are important contributors to serious ailments such as atherosclerosis, alcoholic liver cirrhosis and cancer, the antioxidant property of the extract of E. agallocha as observed in the present study might be useful for the development of newer and more potent antioxidants